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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ec50dea6fb8252504a6785d30b20e7b410fd4bd1b8f3b7849daad83b6555e7d8' 
  AND token = 'T+C9lQGbz8E1Ipkqh0zrnjlv+dmxEyCzEwTcFURYPqY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}