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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '15995697cd01035bda2c6480141168bc9c113e6a11a6494c666d8d3a59622554' 
  AND token = 'P8w5Yy8Bfp21laZxyjYRM3shaOt26WOqVMsaHHuv4ZI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}