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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0f040981d0891726a998d09949b3327daf904b0d0624b8c5c44a266bc1ca3643' 
  AND token = 'M67ajVT8UF4nm7UyfRwOJoYSCUSu2EBOJXvHn0RjkV0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}