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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ec43b31ad0261f13f6a3efbd7e4e3e5052b657418734b77930411d83b254fa65' 
  AND token = '4+HymDAgxgXXZyg9mYAMq1xL3BXz1ac5u+Y9sgrjKEg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}