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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3d646eee1167a60cf051a93acb02bab7109ad20781087db007b75cd26d4ee6e0' 
  AND token = 'xj3lJuRBLaPWZ1v3+pikCkWCRyfQfnal48qgHO5osIA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}