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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42f67443201688006592ed47c793fbad05034bd01583c1b0b6d7897d0e273807' 
  AND token = 'IAOUz1gxHFA8bRgdgph2GN4MEBLFRC4i2DxEI4SOW8I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}