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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '517feaa3a0614530808acf07d33e5ddbcd63e5da54eee788b219a174adb82a22' 
  AND token = 'uU6Hm5x3HtJS1hqwjP1P4OO2EMK5+tbBS7+GSwVmCOc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}