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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3ee15a513b4c670002879c49bb64d86264cf6bfafdd1a8fa9d30673fa53f32b1' 
  AND token = 'BPIB3vJVs6hbcw1WDpmm3kpPSaP7MPWC602DWLPjbmU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}