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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7953598e3513b1ed067d23769223ec37773852fedb96f73b3d7e053f9e26f3a4' 
  AND token = 'nI21JGqxNHj09mEA0u6P9GSd91rP9QvG3y74RiR3CEo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}