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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b501cf7d377b1b95a18a3fe64d0291c2bee6ba38430e10da111e301dcedf6a1c' 
  AND token = '13kp3De47VM1386TtdSOmFZJqjRYR1b5548SSDh6A+o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}