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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '461d153fcf7a46ea5ba4cb97bf739fcb4abb7a68a528de0f02af3bf7af59a271' 
  AND token = 'dkwU9MPc87yKmx/XLOj8kIBNKshcSM6ihnJpS+Iqo2w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}