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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4225929b681ebd1abc5b02f7c401aafc473e8f953c60956d68bd26ba9e30ad4d' 
  AND token = 'hEwvvAP8K+DX6XE1lJtuw0tRIbHXSsWX7cgpaBlmdvA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}