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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9e0bd78038c3e8c49c290800b3666f10e597ea425d4b1cbb59b65e36a3c60e1a' 
  AND token = 'ZOGXB6cBPRsYeqls7LqxiVVAnz6NtJJBs5zmC7XS7i8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}