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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65493f739252a4b6d2266df05fc43c4d679e42880d58988d29f29f4da3dcb162' 
  AND token = 'WCWvl7whUOY906BbVNhvOA4XVxNfuP6+nK86a28lxLQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}