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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52c7dc9f42abc4a51a1021f1aed4bb3b01f094b0471014b2cf1d01f677f680a7' 
  AND token = 'j13W5OaYESx+kLRK1w+10KUY6lV0POuXG9ikGx28Z5c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}