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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3fbee35a4815f12f81b65cd6cec3c8c5dd2b4b335ccec8be40359812a65be378' 
  AND token = 'AxUVqIZ9slJolWMhChWA2mB6qt3keaI7MDuRrBGqlvo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}