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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8eea3912fc910cf528423dd2bef930e409b57ad4bd4b05ab024fd6955eb6f266' 
  AND token = 'lz9kPMyHrIzj9vm+DaqLE1CkuP8/uhTnMY1tRMcVVzY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}