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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5853958d4833e1a4c6639588550fedcce294040a17608762c8a80d005bce1fc2' 
  AND token = 'QHqAF+6l7HePZ5d+Ru+LLv0LaGsLCk7wWYLUTt8IWoA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}