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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a5e22e3844583db3994b813065e29d11c9041ec0a18fa1f3e3a9da1af921dc27' 
  AND token = 'RM0OobII6/1ianhMV9MXVr92wsSeNe12k8TFpE1nMdg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}