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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e7f27d1c53fe5406e9a62250d7b49131e101dc142dd265dbf15a12a1123abf98' 
  AND token = 'D/CIo970p9HYmAd+jARzc7C/XfmzVsEBGP01oAkvcvE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}