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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1224e716e021d83a2ed75ba06af835ab45c63d4dcc678b6c487de60258f0ba49' 
  AND token = '9G3NSy2fmjlhAGSKE1938JiwO7sRbBDcrNibsG2Updg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}