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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0e0e3fb71c8bb6f87dde7c7141627e55fc9405cd23f75a68bc98b55e18ed0181' 
  AND token = '3XfXEbnArunEtcimgE1I9zMgDL8FEe5sZ23wnCcuDy8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}