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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '865da9db544e4bd519a0aac58bc89e7a912f01d7e5a2f82d70644b24fca23bab' 
  AND token = '3ppry/wB8tvS5g74q/WZHyRBSbizctlriT3E8bZouTk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}