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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd580f997a2e3693acdf5512d2db4ca637fc2783f2b615f9cf5adca3d19521da8' 
  AND token = 'zpEozpTmUhZ3Gn0a/u/N69O03bd/lwxGvwg0LhpeGM0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}