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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a12f0bcdea90e9c1a805271a80678eb91f2b7475fcd91446d05034960a60429c' 
  AND token = 'FsW+I5cJt4DJR03dIvyYMD3kHlXBh7ljXACSpSjoFPs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}