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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21026c9556f0e55dcdc8d1c6e84fc6995b8091bd0c378f5f3c2f94e9a9eb6c8a' 
  AND token = 'so0XjP4Cdt9yEe94iCI13V4ZTmaxh3tlKYpWvE2zSh4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}