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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1ef26b28bcf73fb18e92b9ed63a374ea36ca902e0377cab60321b0ed0964b30b' 
  AND token = 'vYxh/SJtaTQ00/53GdP+mzsUoKXjh3NVTvYmIhtt9rQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}