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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9221850505d42ea1d6540aced0f754892dc3d1b48fd9ade0ef6759c882c2ac23' 
  AND token = 'zck+HIhwdewn8xeMwJAGuZZWH5TvrGZVjmqafvDR93c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}