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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f2909580df0c016fa561bd8850c2f3dc0f33e6a703461dbbb4f396ce7fe51b03' 
  AND token = 'zwyFl5Gwn5uVScwYduS3nHwgBd1GQWo3kASXZMEvOvg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}