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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4a09dda4fc1562895e393b4f85064c69249f49843a4dc3458eac7e5c1202d085' 
  AND token = 'NpfVgdYzl7upxH+mfHWUDRpFxamTywlz2kpSvWyTA8Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}