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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4ede4ea9b9019687535a3a787a5b4acce03c2ff01f848ba5b5c2bd4bd492fa8b' 
  AND token = 'OrPNMA+QjhW2A4k/E+/nhn0UbYsyi0vGgSRsVyv4cfA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}