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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '57e8c4b478c591b5f186b1db4f9594eec65f4ef7027324e509d0f1211b3a3e4a' 
  AND token = 'cn3x2Sx3e3RCpmIFvdDVGukpYhIXuKjMIV4efM4DHTw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}