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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e43eb50890fb1fe1d612d0cc3218c6890f70ec68314d153174c1b00c27a58c56' 
  AND token = 'VG1C869WLwsrZalAygURxp/GTqnBW1QfQgeTRDzh/3A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}