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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b6a7aa93aa83f796be5154d56d8965ce6d3752513e56bd6e37c1c78224549217' 
  AND token = 'I5+TZ8DoBftTtrX3Bph1MRgUZkY67WDVadc3oC9aceI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}