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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10621354d0a5aa9998b1aec6d959cbfd2fceef658ac9a4265d6b1783cff6437f' 
  AND token = 'WqkL4EVxPjnr1dxkJOpI6tHp9w3BV45xriwQybeP3zY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}