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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ad1e652c60d848659105a87068d663ea3ea7937d912f3d710f929dde846a8ea4' 
  AND token = 'blHVe90wOLJ0j2n0vK+2WVVbJJRiiGY4zUL29nEFGYE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}