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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd53def168f5e33973417b1556c263580cd6ac52e0a443cf66c89488261412809' 
  AND token = 'rZea2Zr+gyvHRR+kt22JF8QjooBKgU4sMqt2XCdJEvI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}