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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af860cf287db3c63a48e6bb9b2e8c12f106e7ba1e7fe0eee0728f501765ceb9c' 
  AND token = 'Dhtj860Ad/i7f+ey1gILYrMF+wGRoXGSqeOP6w63WTI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}