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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '14ad07463dc42fdbaea13cd1728f5ecb921586d617e575bcf3bf824ac585a487' 
  AND token = 'hIi07Q+LVQhoSrol5zcQU7sWoJPhQFh1UnkC1RltkXQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}