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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b22413a7d36e262e93ca326f6c3ae5b9619725dac484840e474014b4189f992a' 
  AND token = 'X4wOpC+k+z0efQB57qtofkht4NV44x76E/LdROiY9AY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}