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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '24e7367c49a4e6640030afca38dafbaaf1ffe070c97042b4da57180ad1e9021b' 
  AND token = '+uhPrPSVwzfMerO402eh7yVLGMCsifNUXxHfLOnAPmM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}