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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '14f5399a3863f81004163c4e8751f48e0c4c6c9b11b0ff3080e02cd5ddf7e750' 
  AND token = 'a8eRN6mXV+YO26N4qj9r6T4EsBbxhM6ScE9nxDiC4QA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}