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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '643562a5d6a69f2ce4df87261f5da2b40b3a87c21a4234b451a1272d1e3cca40' 
  AND token = 'vIOiS2SqfCwTBczGeoP6VdDMZ5sJRJ6vlhFCe22YJKQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}