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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0d827119bf3d81c73101f89639a2aa5907ee3403deec332c1709016addd3a9a7' 
  AND token = 'Tkm6R9kvFmkgz3E8cFCHKsJJeqT1oApJaX82d+RbvRM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}