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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42ff7e4d8cdb12d502e32a7491536fc9d89ad32afd9b08c41b1ad53bf06e357f' 
  AND token = '8qvk4acTTiPpAQYjho9EEXSLsDnm0xTkjZYTHT4WyvE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}