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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a4603374730dcbb835f9129e7477b88636324f2d21c9e7a11afdd352b95f4ff0' 
  AND token = 'ZrSzgiDL3tm/sstdZwqo7E7IpD/M9KC9bbGWWhd6tco=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}