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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49e3aefa383db2b777d82b238b642c7442be6ab7d6a13cbfb7a01d1107a355d5' 
  AND token = '+cf3gsJ3GgCt+d/nHrPPAyfKuW27bL2oq78w2RWwXbM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}