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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b306e60be41b8adda43201bf82a41fd15f1bfc31f04f85da0a1a4e68e56f567' 
  AND token = 'Dfu4V39fgUE5qTrKVFofIbw33jgDwi+39MhvZgNyXKQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}