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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b159abbb6a1736c2b52b90498ebb8de6a52af37c2d5162964429552648567dd1' 
  AND token = 'E4xM8XAxeiqzb+UZNfqOlVRObb9POQXV2lzXDG5OKeQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}