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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c734e8d3a956ec341ca291a822dbf002f3d63c3c3d2e2a18610a33dc41b36cf8' 
  AND token = 'idNpjuKrfEc0VqAKbhtVwUWsqvPQKT9wM/ScyZmxQyk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}